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Nat Genet. 1994 Nov;8(3):297-302.

Murine muscular dystrophy caused by a mutation in the laminin alpha 2 (Lama2) gene.

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  • 1La Jolla Cancer Research Foundation, California 92037.


The classic murine muscular dystrophy strain, dy, was first described almost 40 years ago. We have identified the molecular basis of an allele of dy, called dy2J, by detecting a mutation in the laminin alpha 2 chain gene--the first identified mutation in laminin-2. The G to A mutation in a splice site consensus sequence causes abnormal splicing and expression of multiple mRNAs. One mRNA is translated into an alpha 2 polypeptide with a deletion in domain VI. The truncated protein apparently lacks important qualities of the wild type protein and is unable to provide sufficient muscle stability.

[PubMed - indexed for MEDLINE]
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