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Am J Psychiatry. 1995 Mar;152(3):444-6.

Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis.

Author information

  • 1McLean Brain Imaging Center, McLean Hospital, Belmont, MA 02178.

Abstract

OBJECTIVE:

The authors measured the ratio of N-acetyl aspartate (a putative neuronal marker) to creatine-phosphocreatine in patients with first-episode psychosis by using proton magnetic resonance spectroscopy (MRS).

METHOD:

Temporal lobe 1H MRS was performed bilaterally on 13 patients with first-episode psychosis and 15 comparison subjects. The N-acetyl aspartate/creatine-phosphocreatine and choline/creatine-phosphocreatine ratios were determined.

RESULTS:

The N-acetyl aspartate/creatine-phosphocreatine ratio of the psychotic patients was significantly lower than that of the comparison subjects.

CONCLUSIONS:

These preliminary data suggest that abnormalities in temporal lobe N-acetyl aspartate concentration are present early in psychotic illness.

PMID:
7864274
[PubMed - indexed for MEDLINE]
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