Science. 1995 Feb 17;267(5200):1034-7.

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation.

Source

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2250.

Abstract

Apolipoprotein E (apoE) deficiency causes severe hyperlipidemia and atherosclerosis in humans and in gene-targeted mice. Although the majority of apoE in plasma is of hepatic origin, apoE is synthesized by a variety of cell types, including macrophages. Because macrophages derive from hematopoietic cells, bone marrow transplantation was used to examine the potential of apoE synthesized by bone marrow-derived cells to correct the hyperlipidemia and atherosclerosis caused by apoE deficiency. After transplantation of bone marrow from mice with the normal apoE gene into apoE-deficient mice, apoE was detected in serum and promoted clearance of lipoproteins and normalization of serum cholesterol levels. ApoE-deficient mice given transplants of normal bone marrow showed virtually complete protection from diet-induced atherosclerosis.

PMID:: 7863332; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Molecular Biology Databases

CHOLESTEROL - HSDB

Supplemental Content

Save items

Related citations in PubMed

Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosis. [Arterioscler Thromb Vasc Biol....]
Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosis.
Van Eck M, Herijgers N, Yates J, Pearce NJ, Hoogerbrugge PM, Groot PH, Van Berkel TJ. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):3117-26.
Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice. [Biochem Biophys Res Commun. 2004]
Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice.
Shi W, Wang X, Wong J, Hedrick CC, Wong H, Castellani LW, Lusis AJ. Biochem Biophys Res Commun. 2004 Apr 23; 317(1):223-9.
Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis. [Atherosclerosis. 2001]
Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis.
Van Eck M, Van Dijk KW, Herijgers N, Hofker MH, Groot PH, Van Berkel TJ. Atherosclerosis. 2001 Jan; 154(1):103-12.
Review The key role of apolipoprotein E in atherosclerosis. [J Mol Med (Berl). 2005]
Review The key role of apolipoprotein E in atherosclerosis.
Greenow K, Pearce NJ, Ramji DP. J Mol Med (Berl). 2005 May; 83(5):329-42. Epub 2005 Apr 13.
Review The cell and molecular biology of apolipoprotein E synthesis by macrophages. [Ciba Found Symp. 1986]
Review The cell and molecular biology of apolipoprotein E synthesis by macrophages.
Werb Z, Chin JR, Takemura R, Oropeza RL, Bainton DF, Stenberg P, Taylor JM, Reardon C. Ciba Found Symp. 1986; 118:155-71.

See reviews... See all...

Cited by 50 PubMed Central articles

Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia. [PLoS One. 2011]
Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia.
Georgiadou D, Chroni A, Vezeridis A, Zannis VI, Stratikos E. PLoS One. 2011; 6(11):e27037. Epub 2011 Nov 1.
ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. [J Clin Invest. 2011]
ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice.
Murphy AJ, Akhtari M, Tolani S, Pagler T, Bijl N, Kuo CL, Wang M, Sanson M, Abramowicz S, Welch C, et al. J Clin Invest. 2011 Oct; 121(10):4138-49.
Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions. [J Biol Chem. 2011]
Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions.
Trusca VG, Fuior EV, Florea IC, Kardassis D, Simionescu M, Gafencu AV. J Biol Chem. 2011 Apr 22; 286(16):13891-904. Epub 2011 Mar 3.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow ...
Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation.
Science. 1995 Feb 17 ;267(5200):1034-7.

PubMed
Lymphangioma of the mesentery and small intestine: a case report showing a solid...
Lymphangioma of the mesentery and small intestine: a case report showing a solid tumor with a cystic component on US and CT.
Radiat Med. 1994 Sep-Oct ;12(5):241-3.

PubMed
Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes.
Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes.
Prog Nucleic Acid Res Mol Biol. 1994 ;49:241-83.

PubMed
Metastasizing erythroplasia Queyrat. Report of a case.
Metastasizing erythroplasia Queyrat. Report of a case.
Acta Derm Venereol. 1976 ;56(5):409-12.

PubMed
Rotator cuff disorders: interobserver and intraobserver variation in diagnosis w...
Rotator cuff disorders: interobserver and intraobserver variation in diagnosis with MR imaging.
Radiology. 1995 Mar ;194(3):831-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 50 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information