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The ins and outs of Raf kinases.
Institute of Medical Radiobiology and Cell Biology, University of Würzburg, Germany.
Raf kinases are signal-integrating enzymes that have the ability to switch tyrosine kinase signalling to serine/threonine phosphorylation and connect growth factor receptors with transcription factors. The connection involves a cascade of protein kinases that is essential for cellular proliferation and differentiation of species ranging from worms to humans. This cascade also mediates transformation by most oncogenes.
PMID: 7855890 [PubMed - indexed for MEDLINE]
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Cited by 50 PubMed Central articles
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A-RAF kinase functions in ARF6 regulated endocytic membrane traffic.
Nekhoroshkova E, Albert S, Becker M, Rapp UR.
PLoS One. 2009; 4(2):e4647. Epub 2009 Feb 27.
[PLoS One. 2009]
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A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosis.
Borysov SI, Guadagno TM.
Mol Biol Cell. 2008 Jul; 19(7):2907-15. Epub 2008 Apr 23.
[Mol Biol Cell. 2008]
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Survival signaling by C-RAF: mitochondrial reactive oxygen species and Ca2+ are critical targets.
Kuznetsov AV, Smigelskaite J, Doblander C, Janakiraman M, Hermann M, Wurm M, Scheidl SF, Sucher R, Deutschmann A, Troppmair J.
Mol Cell Biol. 2008 Apr; 28(7):2304-13. Epub 2008 Jan 22.
[Mol Cell Biol. 2008]
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