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Neurology. 1995 Feb;45(2):384-5.

Frequency of anti-nuclear antibodies in multiple sclerosis.

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  • 1Department of Neurology, University of Rochester Medical Center, NY.


We found anti-nuclear antibodies (ANA) in 26.7% of 150 relapsing-remitting and in 30.4% of 23 chronic progressive definite multiple sclerosis (MS) patients by retrospective chart review. These patients did not have systemic lupus erythematosus. Since ANA are not pathogenically relevant in MS, they are false-positive, and likely reflect systemic immune dysregulation in MS.

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