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Arch Pediatr Adolesc Med. 1995 Feb;149(2):206-9.

Theophylline does not shorten hospital stay for children admitted for asthma.

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  • 1Department of Pediatrics, University of Maryland School of Medicine, Baltimore.

Abstract

OBJECTIVE:

To determine if the use of intravenous theophylline, in the form of aminophylline, when added to systemic corticosteroids and aerosolized beta 2-agonists, enhances the improvement of children with acute asthma exacerbations.

DESIGN:

A double-blind, placebo-controlled, randomized, clinical trial.

SETTING:

The University of Maryland Medical Center, Baltimore, an urban primary- and tertiary-care pediatric medical center.

PATIENTS:

Forty-two children, aged 2 to 18 years, admitted to the hospital for acute exacerbations of asthma.

METHODS:

Patients were randomized to receive either intravenous theophylline to maintain a serum level greater than 55 mumol/L or a placebo infusion. All patients received methylprednisolone and nebulized albuterol. A clinical severity score was assessed twice daily.

RESULTS:

The mean length of stay for the treatment and control groups was 52.3 +/- 32.3 hours and 48.2 +/- 26.6 hours, respectively (t = 0.45, P = .65). The rate of improvement of clinical scores was similar.

CONCLUSION:

These data suggest that the addition of theophylline to albuterol and corticosteroids does not enhance improvement of children admitted to the hospital with asthma.

PMID:
7849886
[PubMed - indexed for MEDLINE]
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