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    Science. 1995 Feb 3;267(5198):682-5.

    Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.

    Dérijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, Davis RJ.

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    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605.

    Erratum in

    • Science 1995 Jul 7;269(5220):17.

    Abstract

    Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38 subgroups. These MAP kinase isoforms are activated by dual phosphorylation on threonine and tyrosine. Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. These MKK isoforms did not activate the ERK subgroup of MAP kinases, but MKK4 did activate JNK. These data demonstrate that the activators of p38 (MKK3 and MKK4), JNK (MKK4), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.

    PMID:
    7839144
    [PubMed - indexed for MEDLINE]

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