Dissociation of selective renal venous plasma endothelin-1 activity and corresponding plasma renin activity in a patient with hypertension, severe stenosis of unilateral renal artery and ipsilaterally decreased renal function

Nephron. 1994;68(3):372-4. doi: 10.1159/000188402.

Abstract

Plasma endothelin-1 (ET-1)-like immunoreactivity in selective renal venous blood and peripheral venous blood was measured and compared with plasma renin activity and aldosterone level in a 26-year-old woman with suspected renovascular hypertension due to stenosis of the left renal artery. Although there was no significant step-up in plasma renin activity between the right and the left renal vein, left/right ratio of plasma ET-1 in the renal vein was 2.18. This case suggests that ET-1 may be one of the hypertensive mechanisms of suspected renovascular hypertension in addition to the renin-angiotensin system.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aldosterone / blood
  • Endothelins / blood*
  • Female
  • Humans
  • Hypertension, Renovascular / blood
  • Hypertension, Renovascular / diagnosis*
  • Hypertension, Renovascular / etiology
  • Kidney / blood supply
  • Kidney / diagnostic imaging
  • Kidney / physiology*
  • Kidney Function Tests
  • Organotechnetium Compounds
  • Radioimmunoassay
  • Radionuclide Imaging
  • Renal Artery Obstruction / blood*
  • Renal Artery Obstruction / complications
  • Renal Artery Obstruction / diagnostic imaging
  • Renal Artery Obstruction / physiopathology
  • Renin / blood*
  • Succimer
  • Technetium Tc 99m Dimercaptosuccinic Acid

Substances

  • Endothelins
  • Organotechnetium Compounds
  • Technetium Tc 99m Dimercaptosuccinic Acid
  • Aldosterone
  • Succimer
  • Renin