JAMA. 1995 Feb 8;273(6):489-90.

Chaparral ingestion. The broadening spectrum of liver injury caused by herbal medications.

Gordon DW, Rosenthal G, Hart J, Sirota R, Baker AL.

Source

Department of Medicine, University of Chicago Hospitals, IL 60637.

Abstract

Unconventional medical practices, including the use of herbal remedies, are prevalent in the United States. Chaparral is an herbal preparation made from a desert shrub and used for its antioxidant properties. We report the case of a 60-year-old woman who took chaparral for 10 months and developed severe hepatitis for which no other cause could be found. Despite aggressive supportive therapy, the patient deteriorated and required orthotopic liver transplantation. She is now well, more than 1 year after her transplant. This case suggests that chaparral can cause serious liver injury and fulminant hepatic failure. Herbal medications should be considered as potential causes of liver toxicity.

Comment in

PMID:: 7837368; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

Nordihydroguaiaretic Acid

LinkOut - more resources

Full Text Sources

Supplemental Content

Icon for Silverchair Information Systems

Save items

Related citations in PubMed

Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf. [J Clin Gastroenterol. 1990]
Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf.
Katz M, Saibil F. J Clin Gastroenterol. 1990 Apr; 12(2):203-6.
Chaparral-associated hepatotoxicity. [Arch Intern Med. 1997]
Chaparral-associated hepatotoxicity.
Sheikh NM, Philen RM, Love LA. Arch Intern Med. 1997 Apr 28; 157(8):913-9.
Chaparral-induced hepatic injury. [Am J Gastroenterol. 1995]
Chaparral-induced hepatic injury.
Batchelor WB, Heathcote J, Wanless IR. Am J Gastroenterol. 1995 May; 90(5):831-3.
Review [Liver toxicity of drugs of plant origin]. [Z Gastroenterol. 2001]
Review [Liver toxicity of drugs of plant origin].
Stickel F, Seitz HK, Hahn EG, Schuppan D. Z Gastroenterol. 2001 Mar; 39(3):225-32, 234-7.
Review Liver transplantation for disulfiram-induced fulminant hepatic failure. [J Clin Gastroenterol. 2004]
Review Liver transplantation for disulfiram-induced fulminant hepatic failure.
Mohanty SR, LaBrecque DR, Mitros FA, Layden TJ. J Clin Gastroenterol. 2004 Mar; 38(3):292-5.

See reviews... See all...

Cited by 8 PubMed Central articles

Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb. [Gut Liver. 2011]
Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb.
Jung KA, Min HJ, Yoo SS, Kim HJ, Choi SN, Ha CY, Kim HJ, Kim TH, Jung WT, Lee OJ, et al. Gut Liver. 2011 Dec; 5(4):493-9. Epub 2011 Nov 21.
Drug-induced Liver Injury. [US Gastroenterol Hepatol Rev. ...]
Drug-induced Liver Injury.
David S, Hamilton JP. US Gastroenterol Hepatol Rev. 2010 Jan 1; 6:73-80.
Review Drug-induced liver injury: is it somehow foreseeable? [World J Gastroenterol. 2009]
Review Drug-induced liver injury: is it somehow foreseeable?
Tarantino G, Di Minno MN, Capone D. World J Gastroenterol. 2009 Jun 21; 15(23):2817-33.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Chaparral ingestion. The broadening spectrum of liver injury caused by herbal me...
Chaparral ingestion. The broadening spectrum of liver injury caused by herbal medications.
JAMA. 1995 Feb 8 ;273(6):489-90.

PubMed
Depression in Alzheimer's disease patients: caregivers as surrogate reporters.
Depression in Alzheimer's disease patients: caregivers as surrogate reporters.
J Am Geriatr Soc. 1995 Feb ;43(2):150-5.

PubMed
Compliance: definitions and key issues.
Compliance: definitions and key issues.
J Clin Psychiatry. 1995 ;56 Suppl 1:4-8; discussion 9-10.

PubMed
Strength training increases insulin action in healthy 50- to 65-yr-old men.
Strength training increases insulin action in healthy 50- to 65-yr-old men.
J Appl Physiol. 1994 Sep ;77(3):1122-7.

PubMed
Answers to questions in relation to oral rehydration therapy.
Answers to questions in relation to oral rehydration therapy.
Indian J Public Health. 1994 Apr-Jun ;38(2):87-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: