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Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15.
Nakagawara K,
Mori M,
Takasawa S,
Nata K,
Takamura T,
Berlova A,
Tohgo A,
Karasawa T,
Yonekura H,
Takeuchi T, et al.
Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan.
CD38 has been used as a phenotype marker of lymphocyte differentiation. Recently, we have demonstrated that cyclic ADP-ribose can be synthesized and hydrolyzed by CD38 and acts as a second messenger in insulin secretion from pancreatic beta-cells. We have mapped the CD38 gene to human chromosome 4p15 by fluorescence in situ hybridization.
PMID: 7835083 [PubMed - indexed for MEDLINE]
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