Topical corticosteroid therapy and its effect on the hypothalamic-pituitary-adrenal axis

Dermatologica. 1976:152 Suppl 1:173-80. doi: 10.1159/000257888.

Abstract

All clinically effective topical corticosteroids have the potential for suppressing the pitutary-adrenal axis if large amounts are applied under occlusion on extensive areas. Recovery of the axis function occurs rapidly. In children, however, the risk of chronic suppression of the adrenal axis function with impairment of growth after topical treatment with potent steroids is a real one. Potent steroids in children should, therefore, only be used on refractory areas with carefully controlled quantities.

Publication types

  • Review

MeSH terms

  • 17-Hydroxycorticosteroids / urine
  • Administration, Topical
  • Adolescent
  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / pharmacology*
  • Adrenal Glands / drug effects*
  • Adult
  • Betamethasone Valerate / pharmacology
  • Blood Glucose
  • Child
  • Flumethasone / pharmacology
  • Humans
  • Hydrocortisone / blood
  • Hypothalamus / drug effects*
  • Infant
  • Insulin
  • Metyrapone
  • Pituitary Gland / drug effects*

Substances

  • 17-Hydroxycorticosteroids
  • Adrenal Cortex Hormones
  • Blood Glucose
  • Insulin
  • Betamethasone Valerate
  • Flumethasone
  • Hydrocortisone
  • Metyrapone