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Polymorphism of the gene encoding a human minimal potassium ion channel (minK).
Department of Medicine, University of Rochester Medical Center, NY 14642.
A gene (minK) that encodes a minimal potassium channel has been cloned recently. We describe in this paper a human minK sequence which differs from the original sequence with a single A-->G at position 112. This resulted in a change from a Ser codon (AGT) to a Gly codon (GGT) and created a new MspAI restriction site. Of the 32 alleles from 16 subjects studied, 25 had this newly discovered sequence and 7 had the previously described sequence.
PMID: 7828904 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Potassium channel gene mutations rarely cause atrial fibrillation.
Ellinor PT, Petrov-Kondratov VI, Zakharova E, Nam EG, MacRae CA.
BMC Med Genet. 2006 Aug 3; 7:70. Epub 2006 Aug 3.
[BMC Med Genet. 2006]
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Genetic polymorphisms in KCNQ1, HERG, KCNE1 and KCNE2 genes in the Chinese, Malay and Indian populations of Singapore.
Koo SH, Ho WF, Lee EJ.
Br J Clin Pharmacol. 2006 Mar; 61(3):301-8.
[Br J Clin Pharmacol. 2006]
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The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia.
Scherer CR, Lerche C, Decher N, Dennis AT, Maier P, Ficker E, Busch AE, Wollnik B, Steinmeyer K.
Br J Pharmacol. 2002 Nov; 137(6):892-900.
[Br J Pharmacol. 2002]
Patient Drug Information
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Potassium (Glu-K® , K+ 10® , K+ 8® , ...)
Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...