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Psychiatry Res. 1994 Aug;53(2):153-9.

Cluster a personality disorder: a marker of worse treatment outcome of major depression?

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  • 1Department of Psychiatry, Fujita Health University School of Medicine, Toyookadai Hospital, Ehime-ken, Japan.


This study attempted to identify a specific personality disorder (PD) cluster associated with poor outcome after a 4-month course of antidepressant therapy. Subjects were 96 consecutive outpatients with major depression. The Structured Clinical Interview for DSM-III-R (SCID) was used to make Axis I and Axis II diagnoses. To evaluate the net effect of each PD cluster on the outcome of depression, a log-linear model was applied. The analysis showed that the presence of a PD from cluster A was significantly correlated with the 4-month outcome of depression.

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