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Neurosci Lett. 1994 Aug 15;177(1-2):162-4.

Human cortical neuronal (HCN) cell lines: a model for amyloid beta neurotoxicity.

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  • 1Department of Central Nervous System Research, Lilly Research Laboratory, Lilly Corporate Center, Indianapolis, IN 46285.


Human cortical neuronal cell lines HCN-1A and HCN-2 are killed for following exposure of the differentiated cells to amyloid beta-peptide(1-40), a component of senile plaques and other amyloid deposits in brains from Alzheimer's patients. We present a model of A beta toxicity uncomplicated by the presence of other cell types that can be used to address the mechanism of A beta neurotoxicity. This model will be useful in the evaluation of neuroprotective compounds which may attenuate cortical neuronal loss in Alzheimer's disease.

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