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    J Biol Chem. 1995 Jan 13;270(2):503-6.

    Lipid modifications of trimeric G proteins.

    Wedegaertner PB, Wilson PT, Bourne HR.

    Department of Pharmacology, University of California, San Francisco 94143.

    G protein alpha subunits and beta gamma dimers are covalently modified by lipids. The emerging picture is one in which attached lipids provide more than just a nonspecific "glue" for sticking G proteins to membranes. We are only beginning to understand how different lipid modifications of different G protein subunits affect specific protein-protein interactions and localization to specific cellular sites. In addition, regulation of these modifications, particularly palmitoylation, can provide new ways to regulate signals transmitted by G proteins.

    PMID: 7822269 [PubMed - indexed for MEDLINE]

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