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Gene. 1994 Dec 15;150(2):415-6.

Lissencephaly-1 is one of the most conserved proteins between mouse and human: a single amino-acid difference in 410 residues.

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  • 1Amgen Inc., Thousand Oaks, CA 91320.


The nucleotide (nt) sequence of the LIS-1 cDNA encoding the murine lissencephaly-1 (LIS-1) protein has been determined. The deduced protein shows a very high degree (99.8%) of homology with human LIS-1, having a single conservative amino acid (aa) change out of 410 aa and is identical to a subunit of bovine platelet-activating factor (PAF) acetylhydrolase.

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