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Bone disease after jejuno-ileal bypass for obesity.
Bone tissue was examined in 21 patients who had undergone jejuno-ileal bypass for obesity between 1971 and 1974. 10 patients had osteomalacia with evidence of secondary hyperparathyroidism. Clinical symptoms and biochemical and radiological investigations were often unreliable in diagnosing bone disease, although plasma-25-hydroxyvitamin-D and plasma-phosphate concentrations were significantly lower and plasma-parathyroid-hormone concentrations were significantly higher in the patients with bone disease. The presence of osteomalacia was unrelated to age, length of time since bypass, or post-bypass weight-loss, and plasma-25-hydroxyvitamin-D levels did not correlate closely with bone histological changes. It is concluded that osteomalacia is common after jejuno-ileal bypass and that factors other than simple vitamin-D deficiency may contribute to its development.
PMID: 78209 [PubMed - indexed for MEDLINE]
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Cited by 34 PubMed Central articles
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Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density.
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[Gut. 2004]
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Absorption of calcium and magnesium in patients with intestinal resections treated with medium chain fatty acids.
Haderslev KV, Jeppesen PB, Mortensen PB, Staun M.
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[Gut. 2000]
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Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial.
Christensen JH, Gustenhoff P, Korup E, Aarøe J, Toft E, Møller J, Rasmussen K, Dyerberg J, Schmidt EB.
BMJ. 1996 Mar 16; 312(7032):677-8.
[BMJ. 1996]
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