Indian J Physiol Pharmacol. 1994 Jul;38(3):223-5.

Pharmacological effects of Azadirachta indica (neem) leaf extract on the ECG and blood pressure of rat.

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Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly.

Erratum in

Indian J Physiol Pharmacol 1994 Oct;38(4):239.

Abstract

Neem leaf alcoholic extract (NLE) was investigated for its effects on the ECG and blood pressure of rat. Intravenous administration of NLE (100, 300 and 1000 mg/kg) resulted in initial bradycardia followed by cardiac arrhythmia in rats. NLE produced a significant and dose-related fall in blood pressure which was immediate, sharp and persistent. Pre-treatment with either atropine or mepyramine failed to prevent the hypotensive effect of NLE.

PMID:: 7814089; [PubMed - indexed for MEDLINE]

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