Send to:

Choose Destination
See comment in PubMed Commons below
Biol Psychiatry. 1994 Oct 1;36(7):467-71.

Pharmacogenetic response to antidepressants in a multicase family with affective disorder.

Author information

  • 1Department of Psychiatry, University of Western Ontario, London, Canada.


Eight members from two generations of a family met the DSM-III-R criteria for major depression. Four individuals had severe prolonged depressive disorders that did not respond to standard therapeutic doses of tricyclic and new generation antidepressants, but subsequently responded to the monoamine oxidase inhibitor, tranylcypromine. The literature on pharmacogenetics of the antidepressants is sparse. The pattern of selective response to tranylcypromine in this family supports the view that there is a familial tendency to respond to specific antidepressants or antidepressant groups. A history of response to a specific antidepressant in a relative may be helpful when selecting an antidepressant. Families demonstrating preferential response to specific psychotropics may be suitable pedigrees in which to perform linkage analysis using candidate genes related to the site of action of that psychotropic drug.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk