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Regulation and functions of the glycogen synthase kinase-3 subfamily.
Division of Cell and Molecular Biology, Ontario Cancer Institute, Toronto, Canada.
Glycogen synthase kinase-3 is a 'black sheep' among protein kinases. Although its name suggests a primary function in intermediary metabolism, its scope is far more diverse as indicated by both genetic and biochemical evidence. Over the past five years the enzyme has emerged as an important component of transduction pathways ultimately regulating cell fate and differentiation. The molecular mechanisms underlying these functions are only just being unraveled but point to a novel mode of cellular regulation conserved in all eukaryotes.
PMID: 7803763 [PubMed - indexed for MEDLINE]
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Cited by 10 PubMed Central articles
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NDRG2 expression decreases with tumor stages and regulates TCF/beta-catenin signaling in human colon carcinoma.
Kim YJ, Yoon SY, Kim JT, Song EY, Lee HG, Son HJ, Kim SY, Cho D, Choi I, Kim JH, et al.
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[Carcinogenesis. 2009]
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ReviewProcessive phosphorylation: mechanism and biological importance.
Patwardhan P, Miller WT.
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[Cell Signal. 2007]
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Regulation of the nuclear export of the transcription factor NFATc1 by protein kinases after slow fibre type electrical stimulation of adult mouse skeletal muscle fibres.
Shen T, Cseresnyés Z, Liu Y, Randall WR, Schneider MF.
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[J Physiol. 2007]
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