Creatine kinase elevations with clozapine

M S Keshavan; J Stecker; R K Kambhampati

doi:10.1192/bjp.164.1.118

Creatine kinase elevations with clozapine

Br J Psychiatry. 1994 Jan;164(1):118-20. doi: 10.1192/bjp.164.1.118.

Authors

M S Keshavan¹, J Stecker, R K Kambhampati

Affiliation

¹ Schizophrenia Inpatient Unit, University of Pittsburgh, PA.

PMID: 7802755
DOI: 10.1192/bjp.164.1.118

Abstract

We describe a patient with marked elevations of creatine kinase following institution of clozapine treatment. The enzyme levels promptly subsided with discontinuation of clozapine. The clinical features did not meet any of the published criteria for neuroleptic malignant syndrome.

Publication types

Case Reports

MeSH terms

Adult
Clozapine / adverse effects*
Clozapine / therapeutic use
Creatine Kinase / blood*
Dose-Response Relationship, Drug
Drug Administration Schedule
Humans
Male
Neuroleptic Malignant Syndrome / diagnosis
Neuroleptic Malignant Syndrome / enzymology
Schizophrenia, Paranoid / diagnosis
Schizophrenia, Paranoid / drug therapy*
Schizophrenia, Paranoid / enzymology
Schizophrenia, Paranoid / psychology

Substances

Creatine Kinase
Clozapine