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J Biol Chem. 1995 Jun 30;270(26):15455-8.

Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.

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  • 1Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892-4090, USA.

Abstract

We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.

PMID:
7797535
[PubMed - indexed for MEDLINE]
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