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Eur J Pharmacol. 1995 Mar 16;292(3-4):333-5.

N-acetylcysteine protects against age-related decline of oxidative phosphorylation in liver mitochondria.

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  • 1Instituto de Neurociencias, Facultad de Medicina, Universidad de Alicante, Spain.


Since it has been proposed that oxygen radical inactivation of key enzymes plays a critical role in cell aging, we have investigated the effects of a thiolic free radical scavenger on the oxidative phosphorylation enzymes of liver mitochondria from female OF-1 mice. At 48 weeks of age a control group was fed standard food pellets and another group received pellets containing 0.3% (w/w) of N-acetylcysteine. A 24-week treatment resulted in a significant increase in the specific activities of complex I, IV and V in the hepatic mitochondria of the N-acetylcysteine-treated animals as compared to aged controls.

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