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Arch Dermatol. 1994 Jul;130(7):890-3.

Recurrence of pemphigus vulgaris associated with interleukin 2 therapy.

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  • 1Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.

Abstract

BACKGROUND:

Immunotherapy with recombinant interleukin 2 may result in regression of metastatic cancer, particularly malignant melanoma and renal cell carcinoma.

OBSERVATIONS:

We describe a patient who received interleukin 2 immunotherapy for metastatic renal cell carcinoma. After his second course of treatment, he developed a recurrence of pemphigus vulgaris that had been in remission for 10 years.

CONCLUSIONS:

Interleukin 2 therapy may be associated with recurrence of an autoimmune disease, perhaps because of its ability to stimulate autoantibody production.

PMID:
7794299
[PubMed - indexed for MEDLINE]
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