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FEMS Microbiol Lett. 1995 Jun 1;129(1):17-20.

A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus.

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  • 1Nagoya City Public Health Research Institute, Japan.


A vacuole-formation substance, cereulide of Bacillus cereus, is an emetic toxin in animals. Both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in Suncus murinus, a new animal model of emesis. Vagotomy or a 5-HT3 receptor antagonist completely abolished this emetic effect. Therefore, cereulide causes emesis through the 5-HT3 receptor and stimulation of the vagus afferent. We also found that our purified cereulide caused swelling of mitochondria of HEp-2 cells.

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