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Neurosci Lett. 1995 Feb 17;186(2-3):219-21.

Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia.

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  • 1Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.


We examined IL-6 levels in the cerebrospinal fluid (CSF) of patients clinically diagnosed with Alzheimer-type dementia (ATD) and with vascular dementia (VD) and of age-matched normal subjects. The IL-6 levels in the CSF of ATD, but not VD patients, were significantly decreased. In the early onset ATD patients (disease onset < 65 years), IL-6 levels were reduced to 21% of the control level. The IL-6 levels in the CSF were not associated with the severity of the dementia or the duration of the disease since the identification of the first symptoms.

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