Genetic mapping of the mouse neuromuscular mutatio...[Genomics. 1995]

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1: Genomics. 1995 Jan 1;25(1):207-13. Links

Genetic mapping of the mouse neuromuscular mutation kyphoscoliosis.

Skynner MJ, Gangadharan U, Coulton GR, Mason RM, Nikitopoulou A, Brown SD, Blanco G.

Department of Biochemistry, Charing Cross and Westminster Hospital Medical School, London, United Kingdom.

The ky mouse mutant, kyphoscoliosis, exhibits a degenerative muscle disease resulting in chronic deformation of the spinal column. Using an interspecific backcross segregating the ky mutation, we have mapped the ky locus to a small region of mouse chromosome 9. ky is nonrecombinant with the microsatellites D9Mit24 and D9Mit169 and lies in a conserved linkage group that encompasses human chromosome 3. s-Laminin (LAMS) and the gene for dystrophin-associated glycoprotein 1 (DAG1), which map to human chromosome 3, are both recombinant with ky, ruling them out as candidates.

PMID: 7774920 [PubMed - indexed for MEDLINE]

Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS). [Cytogenet Cell Genet. 1999]
A STS content physical and transcription map across the ky, kyphoscoliosis, nonrecombinant region. [Genomics. 1998]
Mapping of the taurine transporter gene to mouse chromosome 6 and to the short arm of human chromosome 3. [Genomics. 1995]
ReviewMouse chromosome 8. [Mamm Genome. 1992]
ReviewMouse chromosome 11. [Mamm Genome. 1992]

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Genetic mapping of the mouse neuromuscular mutation kyphoscoliosis.

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