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Trends Microbiol. 1995 Mar;3(3):110-4.

Viral potentiation of bacterial superinfection of the respiratory tract.

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  • 1Otological Research Laboratories, Ohio State University, Columbus 43210-1282, USA.


Virus infections of the respiratory tract predispose it to bacterial superinfections. Epidemiological studies, clinical evidence of viral-bacterial co-infection and animal models of such interactions suggest a time course of events and several mechanisms by which viral potentiation may occur. It appears that structural and functional disruption of the respiratory mucosal epithelium is a major contributor to the synergistic effects of superinfection.

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