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Br J Haematol. 1995 Oct;91(2):515-6.
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Br J Haematol. 1996 Mar;92(3):766-7.
t(8;21) myelodysplasia, an early presentation of M2 AML.
Royal South Hants Hospital, Southampton.
The reciprocal translocation of genetic material between chromosomes 8 and 21, t(8;21), is usually restricted to cases of acute myeloid leukaemia (AML). Cases of AML with t(8;21) exhibit characteristic dysplastic features in myeloid and erythroid lineages with reduction in megakaryocytes. We report details of three patients presenting with myelodysplastic features; two had a typical t(8;21), and the third had a variant t(8;21) translocation. We discuss the significance of t(8;21) in the aetiology of myelodysplastic syndrome (MDS) and implications for the management of such patients.
PMID: 7772527 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice.
Grisolano JL, O'Neal J, Cain J, Tomasson MH.
Proc Natl Acad Sci U S A. 2003 Aug 5; 100(16):9506-11. Epub 2003 Jul 24.
[Proc Natl Acad Sci U S A. 2003]
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The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia.
Kogan SC, Lagasse E, Atwater S, Bae SC, Weissman I, Ito Y, Bishop JM.
Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11863-8.
[Proc Natl Acad Sci U S A. 1998]