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Arch Gen Psychiatry. 1995 Jun;52(6):444-55.

Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder.

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  • 1Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook, USA.

Erratum in

  • Arch Gen Psychiatry 1995 Oct;52(10):836.

Abstract

BACKGROUND:

The findings from case reports and patient questionnaire surveys have been interpreted as indicating that administration of stimulants is ill-advised for the treatment of attention-deficit hyperactivity disorder in children with tic disorder.

METHODS:

Thirty-four prepubertal children with attention-deficit hyperactivity disorder and tic disorder received placebo and three dosages of methylphenidate hydrochloride (0.1, 0.3, and 0.5 mg/kg) twice daily for 2 weeks each, under double-blind conditions. Treatment effects were assessed using direct observations of child behavior in a simulated (clinic-based) classroom and using rating scales completed by the parents, teachers, and physician.

RESULTS:

Methylphenidate effectively suppressed hyperactive, disruptive, and aggressive behavior. There was no evidence that methylphenidate altered the severity of tic disorder, but it may have a weak effect on the frequency of motor (increase) and vocal (decrease) tics.

CONCLUSION:

Methylphenidate appears to be a safe and effective treatment for attention-deficit hyperactivity disorder in the majority of children with comorbid tic disorder.

PMID:
7771914
[PubMed - indexed for MEDLINE]
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