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Trends Biochem Sci. 1995 Apr;20(4):156-60.

The mechanisms of DNA topoisomerases.

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  • 1Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.


Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA topology.

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