Chemical characterization of a family of brain lip...[Science. 1995]

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1: Science. 1995 Jun 9;268(5216):1506-9. Links

Chemical characterization of a family of brain lipids that induce sleep.

Cravatt BF, Prospero-Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA.

Department of Chemistry, Scripps Research Institute, La Jolla, CA 92307, USA.

A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition to cis-9,10-octadecenoamide were identified as natural constituents of the cerebrospinal fluid of cat, rat, and human, indicating that these compounds compose a distinct family of brain lipids. Synthetic cis-9,10-octadecenoamide induced physiological sleep when injected into rats. Together, these results suggest that fatty acid primary amides may represent a previously unrecognized class of biological signaling molecules.

PMID: 7770779 [PubMed - indexed for MEDLINE]

ReviewOleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules.
Curr Pharm Des. 1998 Aug; 4(4):303-14.

[Curr Pharm Des. 1998]
Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors.
Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):8078-82.

[Proc Natl Acad Sci U S A. 1996]
Modulation of GABA(A) receptors and inhibitory synaptic currents by the endogenous CNS sleep regulator cis-9,10-octadecenoamide (cOA).
Br J Pharmacol. 1998 Jul; 124(5):873-82.

[Br J Pharmacol. 1998]
The sleep inducing factor oleamide is produced by mouse neuroblastoma cells.
Biochem Biophys Res Commun. 1997 Oct 20; 239(2):473-9.

[Biochem Biophys Res Commun. 1997]
ReviewOleamide: a fatty acid amide signaling molecule in the cardiovascular system?
Cardiovasc Drug Rev. 2007 Spring; 25(1):46-60.

[Cardiovasc Drug Rev. 2007]
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ReviewBiosynthesis, degradation and pharmacological importance of the fatty acid amides.
Farrell EK, Merkler DJ. Drug Discov Today. 2008 Jul; 13(13-14):558-68. Epub 2008 Apr 3.

[Drug Discov Today. 2008]
Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats.
Malone DT, Kearn CS, Chongue L, Mackie K, Taylor DA. Neuroscience. 2008 Mar 3; 152(1):265-72.

[Neuroscience. 2008]
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