Curr Opin Biotechnol. 1994 Aug;5(4):372-80.

Structure prediction of proteins--where are we now?

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European Molecular Biology Laboratory, Heidelberg, Germany.

Abstract

Although the 'structure from sequence' prediction problem remains fundamentally unsolved, new and promising methods in one, two and three dimensions have reopened the field. Significantly improved one-dimensional prediction of secondary structure from multiple sequence alignments is now in routine use. In the two-dimensional approach, inter-residue contacts can be detected by analysis of correlated mutations, albeit with low accuracy. Finally, three-dimensional methods, in which pseudopotentials or information values are derived from the databases, are proving their value for distinguishing between correct and incorrect models.

PMID:: 7765169; [PubMed - indexed for MEDLINE]

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