Biosci Biotechnol Biochem. 1994 Jan;58(1):191-2.

Engineering of cell adhesive immunoglobulin G by grafting the Arg-Gly-Asp cell adhesive signal.

Hashino K, Kato I, Kurosawa Y, Sekiguchi K, Titani K.

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Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Shiga, Japan.

Abstract

A new artificial cell adhesive protein was engineered by grafting the Arg-Gly-Asp (RGD) sequence, the minimal recognition signal of fibronectin for interaction with integrin, to immunoglobulin G (IgG) by in vitro mutagenesis. The mutagenized protein showed cell adhesive activity on baby hamster kidney (BHK) cells.

PMID:: 7764513; [PubMed - indexed for MEDLINE]

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