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Trends Biotechnol. 1993 Sep;11(9):392-6.

Metabolic engineering--methodologies and future prospects.

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  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139.


Attempts to improve the productivity of cellular systems or to increase metabolite yield often require radical alteration of the flux through primary metabolic pathways. However, achieving the desired result often proves difficult because the control architectures at key branch points have evolved to resist flux changes. Identification and characterization of these metabolic nodes is a prerequisite to rational metabolic engineering.

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