Complete design of the optimum immobilized biocatalyst seems to still be a matter of the future. To be successful, it would require numerical determination of all significant parameters at each enzyme engineering phase, that is at the design of the carriers, immobilized biocatalysts and immobilized reactors. Future research trends should follow this strategy. For processing, cellulosic materials have been considered carriers that fulfill requests to an example model: they represent a unique family of carriers that cover a broad variety of physical and chemical properties, immobilizing techniques, and immobilized reactors as well. The reason for writing this review article was to test the reliability of such a processing and subsequently, to confront theoretical considerations with practical applications of biocatalysts immobilized on cellulose materials.