Send to

Choose Destination
See comment in PubMed Commons below
Acta Cytol. 1995 May-Jun;39(3):569-76.

Secretory carcinoma of the breast associated with juvenile papillomatosis in a 12-year-old girl. A case report.

Author information

  • 1Department of Internal Medicine, Kanazawa University Hospital, School of Medicine, Japan.


A rare case of juvenile secretory carcinoma (SC) associated with juvenile papillomatosis (JP) is described. Tumor biopsy and fine needle aspiration cytology (FNAC) were performed in a 12-year-old girl who had noticed a painful right breast mass. One of the two types of tumor cells found on FNAC smears formed mainly sheets or clusters, intercellular spaces within the sheets and intracytoplasmic vacuolation. These cells, a few of which had a signet-ring cell appearance with completely disordered and randomly arranged nuclei, were considered to be SC cells. Cells of the other type were found in scattered papillary clusters and had well-defined cytoplasmic borders, uniform cell and nuclear size, and an orderly nuclear arrangement, suggesting a benign papillary lesion. Histologic examination of the tumor biopsy and breast quadrantectomy specimens revealed SC with JP. The cytologic, histologic and electron microscopic features of SC are described, and the relationship between SC and JP is discussed.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk