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Virus Res. 1995 Feb;35(2):113-21.

Viral oncoprotein binding to pRB, p107, p130, and p300.

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  • 1Department of Biochemistry, School of Medicine and Dentistry, Rochester, NY 14642, USA.

Abstract

The purpose of this review is to bring attention to some additional work in the tumor virus/tumor suppressor field which may have been overshadowed by reports describing adenovirus, SV40, and HPV oncoprotein binding to pRB and p53. The data reviewed herein provide further support for the model that a common mechanism by which DNA tumor viruses transform cells involves inactivation of cellular proteins which function as negative regulators of cell growth.

PMID:
7762286
[PubMed - indexed for MEDLINE]
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