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    Proc Natl Acad Sci U S A. 1995 May 23;92(11):4987-91.

    Isolation and characterization of a MAGE gene family in the Xp21.3 region.

    Muscatelli F, Walker AP, De Plaen E, Stafford AN, Monaco AP.

    Source

    Imperial Cancer Research Fund Laboratories, John Radcliffe Hospital, Oxford, United Kingdom.

    Abstract

    A human gene with strong homology to the MAGE gene family located in Xq27-qter has been isolated by using exon-trapping of cosmids in the Xp21.3 region. We have mapped and sequenced cDNA and genomic clones corresponding to this gene, MAGE-Xp, and shown that the last exon contains the open reading frame and is present in a minimum of five copies in a 30-kb interval. MAGE-Xp is expressed only in testis and, unlike the Xq27-qter MAGE genes, it is not expressed in any of 12 different tumor tissues tested. However, the gene and predicted protein structure are conserved, suggesting a similar function. MAGE-Xp is located in the 160-kb critical interval defined for the locus involved in sex determination within Xp21 and is 50 kb distal to the DAX-1 gene, which is responsible for X-chromosome-linked adrenal hypoplasia congenita.

    PMID:
    7761436
    [PubMed - indexed for MEDLINE]
    PMCID: PMC41832
    Free PMC Article

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