Primary structure of human amphiphysin, the domina...[Hum Mol Genet. 1995]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Hum Mol Genet. 1995 Feb;4(2):265-8. Links

Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14.

Yamamoto R, Li X, Winter S, Francke U, Kilimann MW.

Institut für Physiologische Chemie, Medizinische Fakultät, Ruhr-Universität Bochum, Germany.

Amphiphysin is a protein peripherally associated with synaptic vesicles. It is expressed in many neurons, certain endocrine cell types, and spermatocytes. Autoantibodies against amphiphysin occur in patients afflicted with a rare neurologic autoimmune disease, paraneoplastic Stiff-Man syndrome. To provide a basis for the understanding of anti-amphiphysin autoimmunity, we have cloned cDNAs and determined the primary structure of human amphiphysin. Comparison with chicken amphiphysin defines domains of low and high amino acid sequence conservation. As a candidate for heritable disorders of the nervous system, endocrine tissues or male fertility, the human amphiphysin gene was mapped to chromosome 7, region p13-p14.

PMID: 7757077 [PubMed - indexed for MEDLINE]

Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer.
Mol Med. 1998 Jan; 4(1):29-39.

[Mol Med. 1998]
Autoimmunity in stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161.
FEBS Lett. 1994 Aug 29; 351(1):73-9.

[FEBS Lett. 1994]
The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer.
J Exp Med. 1993 Dec 1; 178(6):2219-23.

[J Exp Med. 1993]
ReviewAutoimmune central nervous system paraneoplastic disorders: mechanisms, diagnosis, and therapeutic options.
Ann Neurol. 1995 May; 37 Suppl 1:S102-13.

[Ann Neurol. 1995]
ReviewStiff-man syndrome: a rare disorder of the central nervous system.
J Neurosci Nurs. 1994 Dec; 26(6):364-6.

[J Neurosci Nurs. 1994]
» See reviews... | » See all...

Cited by 3 PubMed Central articles

The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition.
Casal E, Federici L, Zhang W, Fernandez-Recio J, Priego EM, Miguel RN, DuHadaway JB, Prendergast GC, Luisi BF, Laue ED. Biochemistry. 2006 Oct 31; 45(43):12917-28.

[Biochemistry. 2006]
Stiff-man syndrome.
Rehman HU. Postgrad Med J. 1998 Nov; 74(877):641-2.

[Postgrad Med J. 1998]
Genetic mapping of the human amphiphysin gene (AMPH) at 7p14-p13 excludes its involvement in retinitis pigmentosa 9 or dominant cystoid macular dystrophy.
Yamamoto R, Li X, Francke U, Kilimann MW. Am J Hum Genet. 1995 Oct; 57(4):970-2.

[Am J Hum Genet. 1995]

Recent Activity

Clear Turn Off Turn On

Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-m...Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Display Show

Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic stiff-man syndrome, and mapping of its gene (AMPH) to chromosome 7p13-p14.

Related articles

Cited by 3 PubMed Central articles

Recent Activity