Am J Psychiatry. 1995 Jun;152(6):923-5.

Seasonal rhythm of platelet [3H]imipramine binding in adolescents who attempted suicide.

Pine DS, Trautman PD, Shaffer D, Cohen L, Davies M, Stanley M, Parsons B.

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Division of Child and Adolescent Psychiatry, College of Physicians and Surgeons of Columbia-Presbyterian Medical Center, New York, NY 10032, USA.

Abstract

OBJECTIVE:

This study was designed to determine the seasonality of serotonin functions among adolescents who attempt suicide.

METHOD:

Platelet [3H]imipramine binding was assessed over a period of 18 months in 98 adolescents who attempted suicide and a comparison group of 23 never-suicidal youths with conduct disorder.

RESULTS:

[3H]Imipramine (Bmax) was uncorrelated with age, but showed considerable seasonal variability over time in those who had attempted suicide.

CONCLUSIONS:

[3H]Imipramine binding density in adolescents who attempted suicide exhibited significant seasonality, reaching a nadir in late winter/early spring.

PMID:: 7755125; [PubMed - indexed for MEDLINE]

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