Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 1995 Mar;18(3):143-50.

The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors.

Author information

  • 1Dept of Cell and Developmental Biology, Centro de Investigaciones Biol√≥gicas, C.S.I.C., Madrid, Spain.

Abstract

The multifunctional cytokines of the family of insulin and insulin-like growth factors (IGFs) have not yet gained general recognition as essential cell signals for the development of the vertebrate nervous system. This is, in part, a consequence of previous constraints in our thinking, focused for many years on the endocrine roles of these factors in late mammalian development and postnatal stages. The cellular distribution of the components of the insulin and IGFs signalling system in the developing mammalian and avian CNS is remarkably conserved. While receptors are widespread, the much less abundant factors and modulatory proteins are highly regulated in time and space. Progression of neural development through the steps of cell proliferation, differentiation, maturation and survival is stimulated, at least in culture, by proinsulin and insulin and the IGFs. Thus, these factors might be important autocrine and paracrine signals during development of the CNS.

Comment in

PMID:
7754526
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk