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Science. 1995 May 12;268(5212):880-4.

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+].

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  • 1Department of Biological Sciences, University of Illinois, Chicago 60607-7020, USA.

Abstract

The yeast non-Mendelian factor [psi+] has been suggested to be a self-modified protein analogous to mammalian prions. Here it is reported that an intermediate amount of the chaperone protein Hsp104 was required for the propagation of the [psi+] factor. Over-production or inactivation of Hsp104 caused the loss of [psi+]. These results suggest that chaperone proteins play a role in prion-like phenomena, and that a certain level of chaperone expression can cure cells of prions without affecting viability. This may lead to antiprion treatments that involve the alteration of chaperone amounts or activity.

PMID:
7754373
[PubMed - indexed for MEDLINE]
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