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Mol Cell Biochem. 1995 Jan 12;142(1):9-17.

A model of the pentose phosphate pathway in rat liver cells.

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  • 1Departament de Bioquímica i Fisiologia, Facultat de Química, Universitat de Barcelona, Catalunya, Spain.

Abstract

A mathematical model based on kinetic data taken from the literature is presented for the pentose phosphate pathway in fasted rat liver steady-state. Since the oxidative and non oxidative pentose phosphate pathway can act independently, the complete (oxidative+non oxidative) and the non oxidative pentose pathway were stimulated. Sensitivity analyses are reported which show that the fluxes are mainly regulated by D-glucose-6-phosphate dehydrogenase (for the oxidative pathway) and by transketolase (for the non oxidative pathway). The most influent metabolites were the group ATP, ADP, P1 and the group NADPH, NADP+ (for the non oxidative pathway).

PMID:
7753046
[PubMed - indexed for MEDLINE]
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