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    FEBS Lett. 1995 May 8;364(2):223-8.

    Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.

    Doza YN, Cuenda A, Thomas GM, Cohen P, Nebreda AR.

    Department of Biochemistry, University of Dundee, Scotland, UK.

    A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of Thr-180 and Tyr-182, and that the phosphorylation of both residues is required for the activation of this enzyme.

    PMID: 7750576 [PubMed - indexed for MEDLINE]

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