Biochimie. 1994;76(10-11):1063-70.

The role of H-NS in one carbon metabolism.

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Department of Biological Sciences, Purdue University, W Lafayette, IN 47907, USA.

Abstract

The H-NS protein of Escherichia coli regulates the expression of genes involved in many general processes such as osmoregulation and virulence. More recently, H-NS was shown to exert an effect on ilvIH gene expression in conjunction with the leucine responsive regulatory protein (Lrp). We show that H-NS is involved in the transcriptional regulation of the kbl/tdh operon, which is also Lrp regulated. Insertional inactivation of the hns gene results in two-fold derepression of the kbl/tdh operon. This level of expression is sufficient to suppress the auxotrophic requirements imposed by a glyA mutation. We show that expression of the kbl/tdh operon is temperature controlled and that this control is not mediated through H-NS action as has been shown for some other temperature controlled genes.

PMID:: 7748928; [PubMed - indexed for MEDLINE]

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Synthesis of the Escherichia coli K-12 nucleoid-associated DNA-binding protein H-NS is subjected to growth-phase control and autoregulation. [Mol Microbiol. 1993]
Synthesis of the Escherichia coli K-12 nucleoid-associated DNA-binding protein H-NS is subjected to growth-phase control and autoregulation.
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Cited by 2 PubMed Central articles

Escherichia coli Lrp (leucine-responsive regulatory protein) does not directly regulate expression of the leu operon promoter. [J Bacteriol. 1999]
Escherichia coli Lrp (leucine-responsive regulatory protein) does not directly regulate expression of the leu operon promoter.
Landgraf JR, Boxer JA, Calvo JM. J Bacteriol. 1999 Oct; 181(20):6547-51.
Effects of nutrition and growth rate on Lrp levels in Escherichia coli. [J Bacteriol. 1996]
Effects of nutrition and growth rate on Lrp levels in Escherichia coli.
Landgraf JR, Wu J, Calvo JM. J Bacteriol. 1996 Dec; 178(23):6930-6.

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