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    Nature. 1995 May 18;375(6528):203-11.

    Structural determinants of nuclear receptor assembly on DNA direct repeats.

    Rastinejad F, Perlmann T, Evans RM, Sigler PB.

    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA.

    Comment in:

    Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs. The 1.9 A crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.

    PMID: 7746322 [PubMed - indexed for MEDLINE]

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      Thyroid is a hormone produced by the body. When taken correctly, thyroid is used to treat the symptoms of hypothyroidism (a condition where the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyr...

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