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Genes Dev. 1995 May 1;9(9):1046-58.

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

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  • 1Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724, USA.

Abstract

The Ras and Raf1 proto-oncogenes transduce extracellular signals that promote cell growth. Cdc25 phosphatases activate the cell division cycle by dephosphorylation of critical threonine and tyrosine residues within the cyclin-dependent kinases. We show here that Cdc25 phosphatase associates with raf1 in somatic mammalian cells and in meiotic frog oocytes. Furthermore, Cdc25 phosphatase can be activated in vitro in a Raf1-dependent manner. We suggest that activation of the cell cycle by the Ras/Raf1 pathways might be mediated in part by Cdc25.

PMID:
7744247
[PubMed - indexed for MEDLINE]
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