Croton zehntneri: possible central nervous system effects of the essential oil in rodents

J Ethnopharmacol. 1995 Jan;45(1):53-7. doi: 10.1016/0378-8741(94)01195-6.

Abstract

The effects of essential oil of Croton zehntneri (Euphorbiaceae), orally administered were studied on behavioral parameters using rats and mice. The oil suspension did not modify pentobarbital induced-hypnosis, stereotypic behavior, catalepsy and amphetamine-induced hypermotility. The open-field behaviors were decreased and the minimal convulsant dose of pentylenetetrazole was increased.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine / pharmacology
  • Animals
  • Anticonvulsants / pharmacology
  • Behavior, Animal / drug effects*
  • Brazil
  • Catalepsy / chemically induced
  • Croton Oil / pharmacology*
  • Male
  • Mice
  • Motor Activity / drug effects
  • Pentobarbital / pharmacology
  • Pentylenetetrazole / antagonists & inhibitors
  • Plants, Medicinal / chemistry
  • Rats
  • Rats, Wistar
  • Sleep / drug effects
  • Stereotyped Behavior / drug effects

Substances

  • Anticonvulsants
  • Croton Oil
  • Amphetamine
  • Pentobarbital
  • Pentylenetetrazole