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EMBO J. 1995 Apr 18;14(8):1812-8.

Sequence-dependent bending propensity of DNA as revealed by DNase I: parameters for trinucleotides.

Author information

  • 1International Centre for Genetic Engineering and Biotechnology, (ICGEB), Trieste, Italy.

Abstract

Structural parameters characterizing the bending propensity of trinucleotides were deduced from DNase I digestion data using simple probabilistic models. In contrast to dinucleotide-based models of DNA bending and/or bendability, the trinucleotide parameters are in good agreement with X-ray crystallographic data on bent DNA. This improvement may be due to the fact that the trinucleotide model incorporates more sequence context information than do dinucleotide-based descriptions.

PMID:
7737131
[PubMed - indexed for MEDLINE]
PMCID:
PMC398274
Free PMC Article
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